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The crew of NASA’s SpaceX Crew-11 mission sit inside a Dragon training spacecraft at SpaceX in Hawthorne, California. Pictured from left: Roscosmos cosmonaut Oleg Platonov, NASA astronauts Mike Fincke and Zena Cardman, and JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui (Credit: SpaceX).

NASA’s SpaceX Crew-11 mission is set to launch a four-person crew to the International Space Station later this summer. Some of the crew have volunteered to participate in a series of experiments to address health challenges astronauts may face on deep space missions during NASA’s Artemis campaign and future human expeditions to Mars.

The research during Crew-11 includes simulated lunar landings, tactics to safeguard vision, and other human physiology studies led by NASA’s Human Research Program.

Select crew members will participate in a series of simulated Moon landings, before, during, and after their flight. Using a handheld controller and multiple screens, the astronauts will fly through simulated scenarios created to resemble the lunar South Pole region that Artemis crews plan to visit. This experiment allows researchers to evaluate how different gravitational forces may disorient astronauts and affect their ability to pilot a spacecraft, like a lunar lander.

“Even though many landing tasks are automated, astronauts must still know how to monitor the controls and know when to take over to ensure a safe landing,” said Scott Wood, a neuroscientist at NASA’s Johnson Space Center in Houston coordinating the scientific investigation. “Our study assesses exactly how changes in gravity affect spatial awareness and piloting skills that are important for navigating these scenarios.”

A ground control group completing the same tasks over a similar timeframe will help scientists better understand gravitational effects on human performance. The experiment’s results could inform the pilot training needed for future Artemis crews.

“Experiencing weightlessness for months and then feeling greater levels of gravity on a planet like Mars, for example, may increase the risk of disorientation,” said Wood. “Our goal is to help astronauts adapt to any gravitational change, whether it’s to the Moon, a new planet, or landing back on Earth.”

Other studies during the mission will explore possible ways to treat or prevent a group of eye and brain changes that can occur during long-duration space travel, called spaceflight associated neuro-ocular syndrome (SANS).  

Some researchers suspect the redistribution of bodily fluids in constant weightlessness may increase pressure in the head and contribute to SANS. One study will investigate fluid pressure on the brain while another will examine how the body processes B vitamins and whether supplements can affect how astronauts respond to bodily fluid shifts. Participating crew members will test whether a daily B vitamin supplement can eliminate or ease symptoms of SANS. Specific crew members also will wear thigh cuffs to keep bodily fluids from traveling headward.

Crew members also will complete another set of experiments, called CIPHER (Complement of Integrated Protocols for Human Exploration Research), which measures how multiple systems within the human body change in space. The study includes vision assessments, MRI scans, and other medical exams to provide a complete overview of the whole body’s response to long-duration spaceflight.

Several other studies involving human health and performance are also a part of Crew-11’s science portfolio. Crew members will contribute to a core set of measurements called Spaceflight Standard Measures, which collects physical data and biological samples from astronauts and stores them for other comparative studies. Participants will supply biological samples, such as blood and urine, for a study characterizing how spaceflight alters astronauts’ genetic makeup. In addition, volunteers will test different exercise regimens to help scientists explore what activities remain essential for long-duration journeys.

After landing, participating crew members will complete surveys to track any discomfort, such as scrapes or bruises, acquired from re-entry. The data will help clarify whether mission length increases injury risks and could help NASA design landing systems on future spacecraft as NASA prepares to travel to the Moon, Mars, and beyond.

NASA’s Human Research Program pursues methods and technologies to support safe, productive human space travel. Through science conducted in laboratories, ground-based analogs, and aboard the International Space Station, the program investigates how spaceflight affects human bodies and behaviors. Such research drives NASA’s quest to innovate ways that keep astronauts healthy and mission-ready.

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