Ramped up in power after a two-year upgrade, the world’s most powerful particle accelerator is once again doing science. Following its official restart on June 3, the Large Hadron Collider (LHC) at CERN, Europe’s particle-physics lab near Geneva, Switzerland, can smash protons together faster and with higher energies than during its first run, which ended in February 2013. Our graphical guide illuminates the discoveries that could lie ahead in the next run of the LHC.